Principal Scientist I, Translational Medicine Lab

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.

At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and supporting one another in these pursuits.

Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.

The Translational Medicine Lab plays a pivotal role at Immunocore, generating biological data from both clinical trial and pre-clinical experimental samples to advance understanding of our platform and ultimately improve patients’ health. We are now looking for an enthusiastic and experienced Principal Scientist I to join our team. The successful candidate will lead, design, and conduct experiments to investigate the mechanism of action of our ImmTAX therapies and to test predictive hypotheses using pre-clinical models and patient derived samples.

Key responsibilities
• Lead, design, and conduct experiments to investigate the mechanism of action of ImmTAX and to test predictive hypotheses using pre-clinical models and patient derived samples.
• Design assays to investigate various combination therapies for the purpose of improving efficacy, potency, and safety of our therapeutics.
• Actively contribute to and support the Translational Medicine publication output in high impact journals and key conferences.
• Serve as translational medicine representative in cross functional working groups and committees.
• Mentor and line manage junior members of the Translational Medicine Lab team by providing scientific and technical leadership.
• Keep abreast of technical advances in relevant fields through self-study and attending training sessions and conferences.
• Communicate results internally in lab meetings and seminars and externally in relevant conferences.
• Conduct and analyse experiments and record data in a timely manner following Company procedures.
• Operate in accordance with the company’s health and safety policies.

Experience and Knowledge

Essential
• Advanced knowledge of cancer biology and tumour models.
• Demonstrated extensive experience in dissecting mechanisms of drug resistance in cancers.
• In depth experience in a range of molecular and cellular techniques and immunoassays including:
o Complex cell culture models including 3D cultures and organoids.
o Molecular biology techniques, including generation and validation of stable overexpression (Lentiviral transduction) and CRISPR KO in cancer and/or T cells
o Cellular functional assays including elispots, ELISA, multiplex assays, and killing assays.
• Excellent oral and written communication skills.
• Demonstrated ability to plan and work to agreed deadlines and the ability to work both independently and as part of a team.

Desirable
• Ex vivo analysis of tumour biopsies and tumour infiltrating lymphocytes.
• Experience in mentoring and supervision of junior staff.
• Experience in application of GCP principles to the analysis of clinical trial samples.

Education and qualifications
• PhD in Cancer Biology, Immuno-Oncology, or related discipline.
• At least 8 years of industrial or post-doctoral academic experience.
• Demonstrated record of scientific accomplishments including high impact publications and presentations at conferences.